Log into your Cpanel Control panel, Click on the Auto Responders Icon
Click on the Add Auto-Responder button
Enter the email address for which you want to create the autoresponder
Make sure to select the correct domain in the drop down if you have many domains.
Enter the From information how you would like it to appear
You can insert text in the subject field or leave it deafult, By default messages are sent as plain text. You can select html mode if you like.
Insert the autoresponse text you would like here
Click on Create/modify.
Your autoresponder has now been created. Click on the Go back link
You can now create more autoresponders or modify/delete them.